Ongoing research in targeted therapy, immunotherapy, and gene therapy offers promise for even better outcomes in CML management. Some patients in long-term remission may eventually be able to reduce or stop TKI therapy under close medical supervision.

CML symptoms vary depending on the phase, and many people in the chronic phase experience few or no symptoms. As the disease progresses, however, symptoms may include:

Fatigue and Weakness: Common due to anemia or the energy demands of increased cell production.

Weight Loss: Unexplained weight loss and reduced appetite are often experienced.

Abdominal Discomfort: Swelling in the upper abdomen, caused by an enlarged spleen, can lead to a feeling of fullness even after small meals.

Night Sweats: Patients may experience excessive sweating at night.

Frequent Infections and Bruising: As healthy blood cells decrease, susceptibility to infections increases, along with a tendency to bruise easily.

Bone Pain: Pain in bones or joints may occur, especially in the advanced stages.