Sjögren's Syndrome is a chronic, slowly progressive autoimmune disease that primarily targets the exocrine glands — most notably the lacrimal and salivary glands — resulting in the hallmark symptoms of dry eyes (xerophthalmia / keratoconjunctivitis sicca) and dry mouth (xerostomia). It can occur as a primary condition (pSS) or secondary to another autoimmune disease such as RA, SLE, or systemic sclerosis (sSS). Beyond the sicca complex, Sjögren's causes widespread systemic inflammation affecting the lungs, kidneys, nervous system, skin, and joints. It is associated with autoantibodies anti-Ro/SSA and anti-La/SSB, which are key diagnostic and prognostic markers.