Vasculitis encompasses a heterogeneous group of autoimmune disorders characterised by inflammation and necrosis of blood vessel walls. The resulting vessel wall damage causes luminal narrowing, thrombosis, aneurysm formation, and end-organ ischaemia. Vasculitis is classified by the size of predominantly affected vessels (large, medium, or small), the presence of ANCA antibodies, and specific clinicopathological features. It may be primary (idiopathic autoimmune) or secondary to infection, malignancy, drugs, or other connective tissue diseases. Accurate classification is essential as treatment strategies differ significantly between subtypes.
Clinical Presentation
Currently Licensed States:
Pericarditis, accelerated atherosclerosis, increased MI risk
Pleuritis, pneumonitis, pulmonary hypertension
Episcleritis, scleritis, keratoconjunctivitis sicca
Anaemia of chronic disease, Felty syndrome
Laboratory & Imaging
HLA-DR2/DR3, complement deficiencies (C1q, C4), IRF5, STAT4 gene polymorphisms increase risk.
UV light, infections (EBV), hormonal changes, and drugs (procainamide, hydralazine) can precipitate disease.
B cells produce ANA, anti-dsDNA, and other autoantibodies. T helper cells and type I interferons amplify the response.
Autoantibody-antigen complexes deposit in tissues — kidneys, skin, vessels — activating complement and causing inflammation.
Persistent inflammation leads to fibrosis and functional impairment of target organs if disease remains uncontrolled.
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Rheumatology & Autoimmune Specialist
Providing expert-level autoimmune care with over 30 years of academic medicine experience. Serving Colorado in-person and licensed telemedicine states.
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St. Charbel Rheumatology is located at 3601 S. Pennsylvania St. Suite B, Englewood, CO 80113. Office hours are Monday–Thursday, 8:30 AM – 4:30 PM MT, with limited availability on Fridays. This website is for informational purposes only and does not constitute medical advice. Please consult with a qualified healthcare provider for medical advice, diagnosis, or treatment.